This study introduces a scalable bioreactor using uniformly arranged hollow fiber arrays (HFAs) to produce centimeter-scale engineered tissues, addressing nutrient distribution challenges in cultured meat and tissue engineering. The system ensures minimal necrosis by enabling uniform perfusion, while microfabricated anchors enhance cell alignment for muscle-specific morphology. Active perfusion boosts protein expression, sarcomere formation, and tissue texture. A robotic-assisted assembly method demonstrates scalability, with potential for automation. Future improvements include recyclable materials and edible fibers to enhance sustainability. This platform could revolutionize large-scale tissue biofabrication, offering applications in cellular agriculture and regenerative medicine.
Scalable tissue biofabrication via perfusable hollow fiber arrays for cultured meat applications
ByGrégory Maubon
Apr 19, 2025
By Grégory Maubon
Leading Innovation ++ on the Field ++ with a Purpose => I used AI in cultivated meat industry to optimize bioreactor design and to dramatically improve the efficiency and quality of production. I developed high quality 3D imagery process in a biotechnological startup to disrupt the drug discovery methods.